The safe use of NexGard in pregnant, breeding, or lactating dogs has not been evaluated. In a margin of safety study, NexGard was administered orally to 8 to 9-week-old Beagle puppies at 1, 3, and 5 times the maximum exposure dose (6.3 mg/kg) for three treatments every 28 days, followed by three treatments every 14 days, for a total of six treatments. A third dog with a history of seizures received NexGard and experienced no seizures throughout the study. Dogs in both the treated and control groups that were infested with fleas on Day -1 generated flea eggs at 12- and 24-hours post-treatment (0-11 eggs and 1-17 eggs in the NexGard treated dogs, and 4-90 eggs and 0-118 eggs in the control dogs, at 12- and 24-hours, respectively). NexGard kills adult fleas and is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis), and the treatment and control of Black-legged tick (Ixodes scapularis), American Dog tick (Dermacentor variabilis), Lone Star tick (Amblyomma americanum), and Brown dog tick (Rhipicephalus sanguineus) infestations in dogs and puppies 8 weeks of age and older, weighing 4 pounds of body weight or greater, for one month. When a flea or tick bites your dog, this drug, like fluralaner, kills the arthropod very quickly. Seizures have been reported in dogs receiving isoxazoline class drugs, even in dogs without a history of seizures. Treatment with NexGard may begin at any time of the year (see Effectiveness). Veterinary information provided here is not intended as a substitute for direct consultation with a qualified veterinary professional. The following adverse events reported for dogs are listed in decreasing order of reporting frequency for NexGard: Vomiting, pruritus, lethargy, diarrhea (with and without blood), anorexia, seizure, hyperactivity/restlessness, panting, erythema, ataxia, dermatitis (including rash, papules), allergic reactions (including hives, swelling), and tremors. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Afoxolaner; Orange: Small Dogs: 4 - 10 lbs: 2 to 4 kg: 11.3 mg: Blue: Medium Dogs: 10 - 24 lbs: 4 - 10 kg: 28.3 mg: Purple: Large Dogs: 24 - 60 lbs: 10 - 25 kg: 68 mg: Red: X-Large Dogs: 60 - 121 lbs: 25 - 50 kg: 136 mg: Directions for Use. Afoxolaner has the chemical composition 1-Naphthalenecarboxamide, 4-[5-[3-chloro-5-(trifluoromethyl)-phenyl]-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl. In a 90-day field study, 415 dogs were administered afoxolaner … Copyright © 2021 Animalytix LLC. All Rights Reserved. Care should be taken that the dog consumes the complete dose, and treated animals should be observed for a few minutes to ensure that part of the dose is not lost or refused. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. NexGard (afoxolaner) is for use in dogs only. In case of accidental ingestion, contact a physician immediately. For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or online at http://www.fda.gov/AnimalVeterinary/SafetyHealth. Use with caution in dogs with a history of seizures or neurologic disorders (see Adverse Reactions and Post-Approval Experience). In two separate, well-controlled laboratory studies, NexGard was effective at preventing Borrelia burgdorferi infections after dogs were infested with Ixodes scapularis vector ticks 28 days post-treatment. Store at or below 30°C (86°F) with excursions permitted up to 40°C (104°F). The following adverse events are based on post-approval adverse drug experience reporting. The most frequent reactions reported at an incidence of > 1% within any of the three months of observations are presented in the following table. Afoxolaner kills adult fleas as well as adult ticks. Each chewable is formulated to provide a minimum afoxolaner dosage of 1.14 mg/lb (2.5 mg/kg). QUALITATIVE AND QUANTITATIVE COMPOSITION. Treatment with NexGard may begin at any time of the year. • Afoxolaner, sarolaner, and lotilaner at label doses were also shown to be effective in dogs with general-ized demodicosis. Treatment with NexGard may begin at any time of the year (see Effectiveness). The most frequently reported adverse reactions include vomiting, itching, lethargy, diarrhea, and lack of appetite. If it is suspected that any of the dose has been lost or if vomiting occurs within two hours of administration, redose with another full dose. The safe use of NexGard in pregnant, breeding, or lactating dogs has not been evaluated.Use with caution in dogs … Afoxolaner is a member of the isoxazoline family, shown to bind at a binding site to inhibit insect and acarine ligand-gated chloride channels, in particular those gated by the neurotransmitter gamma-aminobutyric acid (GABA), thereby blocking pre- and post-synaptic transfer of chloride ions across cell membranes. In a well-controlled US field study, which included a total of 333 households and 615 treated dogs (415 administered afoxolaner; 200 administered active control), no serious adverse reactions were observed with NexGard. Another dog with a history of seizures had a seizure 19 days after the third dose of NexGard. For a copy of the Safety Data Sheet (SDS) or to report suspected adverse drug events, contact Merial at 1-888-637-4251 or www.nexgardfordogs.com. https://vetlabel.com/lib/vet/meds/nexgard-1/. In the US field study, one dog with a history of seizures experienced a seizure on the same day after receiving the first dose and on the same day after receiving the second dose of NexGard. In case of accidental ingestion, contact a physician immediately. 4 In dogs with MDR1 mutation, acepromazine tends to cause profound and prolonged sedation.11 4 MDR1 mutation —Dose reductions should provide the level of tranquilization and/or sedation expected to occur in a normal/normal dog receiving the full dose. The dog remained enrolled and completed the study. Dosage. In areas where fleas are common year-round, monthly treatment with NexGard should continue the entire year without interruption. The selective toxicity of afoxolaner between insects and acarines and mammals may be inferred by the differential sensitivity of the insects and acarines’ GABA receptors versus mammalian GABA receptors. The dog remained enrolled and completed the study. Each chewable is formulated to provide a minimum afoxolaner dosage of 1.14 mg/lb (2.5 mg/kg). To minimize the likelihood of flea reinfestation, it is important to treat all animals within a household with an approved flea control product. There are no known contraindications for the use of NexGard. Use with caution in dogs … Terms of Use | Copyright © 2021. At subsequent evaluations post-infestation, fleas from dogs in the treated group were essentially unable to produce any eggs (0-1 eggs) while fleas from dogs in the control group continued to produce eggs (1-141 eggs). ®NexGard is a registered trademark, and ™FRONTLINE VET LABS is a trademark, of Merial. Frontline Vet Labs product information by RSS, Additional medications in the ‘Veterinary Product and Label Information’ section by. Updated: 2020-12-31. Over the 90-day study period, all observations of potential adverse reactions were recorded. Over the 90-day study period, all observations of potential adverse reactions were recorded. At 72 hours post-infestation, NexGard demonstrated >97% effectiveness against Amblyomma americanum for 30 days. In well-controlled laboratory studies, NexGard demonstrated >97% effectiveness against Dermacentor variabilis, >94% effectiveness against Ixodes scapularis, and >93% effectiveness against Rhipicephalus sanguineus, 48 hours post-infestation for 30 days. (2015) Preference of dogs between 2 commercially available oral formulations of ectoparasiticide containing isoxazolines, afoxolaner … No adverse reactions were observed from the concomitant use of NexGard with other medications. In a well-controlled laboratory study, NexGard began to kill fleas four hours after initial administration and demonstrated >99% effectiveness at eight hours. Each chewable is formulated to provide a minimum afoxolaner dosage of 1.14 mg/lb (2.5 mg/kg). Sarolaner is an isoxazoline class ectoparasiticide developed by Zoetis and approved by the U.S. Food and Drug Administration (FDA) in 2016 (Simparica, zoetisus.com).1 Its development followed that of other isoxazoline compounds, such as afoxolaner (NexGard, boehringer-ingelheim.com) and fluralaner (Bravecto, merck-animal-health-usa.com), and preceded that of lotilaner (Credelio, elanco.us). Seizures have been reported in dogs receiving isoxazoline class drugs, even in dogs without a history of seizures. 1Number of dogs in the afoxolaner treatment group with the identified abnormality. A third dog with a history of seizures received NexGard and experienced no seizures throughout the study. Administer the appropriate combination of chewables. Prolonged afoxolaner-induced hyperexcitation results in uncontrolled activity of the central nervous system and death of insects and acarines. NexGard is given orally once a month, at the minimum dosage of 1.14 mg/lb (2.5 mg/kg). The safe use of NexGard in breeding, pregnant or lactating dogs has not been evaluated. NexGard kills adult fleas and is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis) , and the treatment and control of Black-legged tick (Ixodes scapularis) , American Dog tick (Dermacentor variabilis) , Lone Star tick (Amblyomma americanum), and Brown dog tick (Rhipicephalus sanguineus) infestations in dogs and puppies 8 weeks of age and older, weighing 4 pounds of body weight or greater, for one month. Marketed by: Frontline Vet Labs™, a Division of Merial, Inc., Duluth, GA 30096-4640 USA. Shop WalmartPetRx.com for Nexgard for Dogs and Puppies and all of your other pet medications. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the US product label or package insert. Keep NexGard in a secure location out of reach of dogs, cats, and other animals to prevent accidental ingestion or overdose. To optimize drug potency and pharmac… Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Treatment with NexGard may begin at any time of the year. The occurrence of vomiting was generally self-limiting and of short duration and tended to decrease with subsequent doses in both groups. Afoxolaner is a member of the isoxazoline class. 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